Giovanni Antonio Grassi (anglicized as John Anthony Grassi; 10 September 1775 – 12 December 1849) was an Italian Catholic priest and Jesuit who led many academic and religious institutions in Europe and the United States, including Georgetown College in Washington, D.C., and the Pontificio Collegio Urbano de Propaganda Fide in Rome.
Born in the Republic of Venice, Grassi was a promising student of mathematics and the natural sciences, especially astronomy. He completed his studies at the Jesuit College in Polotsk, in the Russian Empire, in 1804 and was appointed rector of the Institute for Nobles.