Mandisa is a feminine given name of South African origin, meaning "sweet". Notable people with the given name include:
Mandisa Hundley (1976–2024), known mononymously as Mandisa, American gospel singer
Mandisa Makesini (fl. 2014–present), South African politician
Mandisa Mashego (born 1973), South African politician and feminist
Mandisa Maya (born 1964), South African judge
Mandisa Mfeka (fl.
